Age-dependent EDC in rat intrapulmonary artery
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چکیده
منابع مشابه
Age-Dependent Regeneration by Using Electromyographical Study Foliowing Sciatic Nerve Injury in Rat
Purpose: There are extensive evidences that show axonal processes of the nervous system (peripheral and/or central) may be degenerated after nerve injuries. Axonal regeneration is relation to various factors. In this investigation we decided to evaluate the effects of nerve regeneration age-dependent on injured rat sciatic nerv. Materials and Methods: For this study, the right sciatic nerve of...
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Greg A. Knock, Anushika S. De Silva, Vladimir A. Snetkov, Richard Siow, Gavin D. Thomas, Mitsuya Shiraishi, Michael P. Walsh, Jeremy P. T. Ward, and Philip I. Aaronson Department of Asthma, Allergy and Respiratory Science and Cardiovascular Division, School of Medicine, King’s College London, London SE1 9RT, United Kingdom; and King’s College London, Smooth Muscle Research Group and Department ...
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The mechanisms through which p38 mitogen-activated protein kinase (p38 MAPK) is involved in smooth muscle contraction remain largely unresolved. We examined the role of p38 MAPK in prostaglandin F(2alpha) (PGF(2alpha))-induced vasoconstriction and in hypoxic pulmonary vasoconstriction (HPV) of rat small intrapulmonary arteries (IPA). The p38 MAPK inhibitors SB-203580 and SB-202190 strongly inhi...
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ATP and UDP constrict rat intrapulmonary arteries, but which receptors mediate these actions is unclear. Here, we used selective agonists and antagonists, along with measurements of P2Y receptor expression, to characterize the receptor subtypes involved. Isometric tension was recorded from endothelium-denuded rat intrapulmonary artery rings (i.d. 200-500 μm) mounted on a wire myograph. Expressi...
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5-Hydroxytryptamine (5-HT) is a potent pulmonary vasoconstrictor and contributes to hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Small intrapulmonary vessels are very sensitive to hypoxia and play a major role for blood flow regulation in the lung. Thus we have investigated the mechanisms involved in the calcium signal to 5-HT in rat small intrapulmonary artery (IPA)....
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1997
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)45174-3